After 5 Years Cervical Cancer Vaccine Tested in Brazil and US Keeps Working

    Young woman gets a cervical cancer vaccine shot

    Young woman gets a cervical cancer vaccine shot As the first FDA-approved cancer vaccine, designed to protect against human papillomavirus, has moved from scientific discussion to social debate, other vaccine studies are continuing to make progress. While HPV vaccine efforts had the "benefit" of a viral source for the disease, other researchers are developing vaccines for cancers that are not virally based, in an effort to coax the immune system into attacking cancerous cells.

    Today at the 2007 Annual Meeting of the American Association for Cancer Research, presentations on ongoing HPV trials and other new approaches to stimulating the immune system are injecting momentum into cancer vaccine research.

    Ongoing evaluation of a phase II trial of a human papillomavirus vaccine, developed to prevent cervical cancer, shows that the vaccine continues to protect against HPV types 16 and 18 at five and a half years into the study, according to researchers from the University of Louisville. Their findings also show that the vaccine offers significant cross-protection for HPV types 45 and 31.

    The study follows 1113 women between the ages of 15 and 25 in North America and Brazil randomized to receive three doses of either the vaccine or the control. The vaccine, made by GlaxoSmithKline, which funded the study, is designed to protect against two strains of HPV, types 16 and 18, which together are thought to cause nearly 72 percent of all cases of cervical cancer.

    At over five years into the study’s follow-up, the researchers found that approximately 98 percent of subjects still maintained protection against HPV types 16 and 18. Regardless of HPV status, the vaccine also appears to prevent most occurrences of cervical intraepithelial neoplasia lesions – abnormal, precancerous cell growths found in the cervix.

    They also found that the vaccination offered significant protection against genetically similar viruses. They determined the vaccine to be 88 percent effective against HPV type 45 and 54 percent effective against HPV type 31.

    "Overall, it is not a surprise that the vaccine offers protection against additional types of human papillomavirus, as they are all related genetically," said Stanley Gall, M.D., professor at the University of Louisville. "However, as you get genetically farther from types 16 and 18, you would expect to see less cross-protection."

    According to Dr. Gall, effective preventative treatment with the vaccine will depend on the long-term and broad protection the vaccine can offer against cancer-causing HPV types.

    Tags:

    • Show Comments (0)

    Your email address will not be published. Required fields are marked *

    comment *

    • name *

    • email *

    • website *

    Ads

    You May Also Like

    For Brazil, Failure Is Not Option in WTO Talks

    Delegates from the 23 developing countries making up G-20 pledged unity and warned in ...

    McCain vs Obama

    Obama and McCain Duke It Out Today in Brazil in Mock Presidential Debate

    A mock US presidential debate will take place today, October 10, from noon to ...

    Rio's Cordão da Bola Preta

    After a Month of Reveling Carnaval Still Going On in Rio, Brazil

    Rio’s City Hall’s balance sheet shows that 4 million people participated in parades on ...

    Street protests in Brazil

    In Brazil, 95% Oppose Black Bloc’s Action

    The Brazilian middle and high classes seem to be the most supportive of the ...

    Poverty and wealth

    The Brazilian Farce: Celebrating World’s Most Miserable 6th Largest Economy

    Having gone through the year-end celebrations we were left with the feeling that 2011, ...

    Brazil’s Auto Parts Sector Expecting to Export US$ 6.7 Billion, an 11% Growth

    Exports of Brazilian auto parts to the Arab countries totalled US$ 23.4 million between ...

    How Brazil Breeders Are Improving Arab Cattle

    The breeders of bovines of the zebu breeds of Brazil are preparing themselves for ...

    Vision of the Seas

    US Cruise Ship Allowed to Go on After Quarantine Imposed by Brazil

    After Brazilian sanitary officials imposed a 24-hour quarantine following a massive outbreak of what ...

    Fire and Poetry

    Who is the Brazilian teenager? He/she is passionate and apathetic, abstemious and drug-addicted, criminal ...

    Brazil Getting Ready for Bush Visit

    Brazil resumes this month the negotiations with the United States for the creation of ...